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Thailand Food Science University

The universal brotherhood and comparative relegion , Part 4 ,the cow

The cow  in many religious Scriptures and books.

        ( as in the Torah, Quran, Gita and Bible)

                By              Prof Ghulam Mohyuddin Wani

                               BVSC&AH,MVSC(VOG)DVM,PhD                             

INTRODUCTION

The cow has been respected and honoured creature in all the religious books and scriptures. Most of the riots and killing in India in the past has been on this issue. The warrior factions perhaps never knew that all the religions of the world as viewed from the holly books the Quran,Gita,Bibel and Torah have mention of the cow. The Quran the holly book of GOD names it many times and full chapter  is named the COW ,AL-BAQUAR.This articles reviews the information to bring a universal brotherhood and common understanding of One GOD ,call him Allah,khuda or bagvan he is one and only one.

First of all I must apologize for any theological mistakes as I am a scientist of the animal sciences and not of the theology. My intension here is to represent the cow more as a scientific miracle than a religious belief. The cow  feeds us all on her milk made of her blood .She  like our mother is to have a due respect in all societies and cultures. I know of my culture we in OLD JOOS{may be Jews ,wandering tribe of Israel}Khowaja or now named as wani always call a cow GAW MUOG the mother cow and loved her,the tradition goes even today in kashmir.

 We will discuss the cow in three sections .In section 1 we shall reveiw the information from websites on the description and interpretation of various holly books .THIS INFORMATION HAS BEEN COLLECTED FRON THE WEB AND  IS ACKNOWLEDGED.The section 2 shall be a scientific interpretation  given by the learned in the field of  concerned theology .The third and last concluding paras shall be based on our own scientific and philosophic metamorphosis and analysis mostly from the reference materials published by Anil Chawla.

We apologize in advance for omissions and ask all of you to please inform us about your views and criticize it ,so as to act PEERS of our forthcoming book .

Although the chapter 2 of the holly Quran is named the cow or the Al-Baqarah.Being the chapter in which most of the tenements of the religious beliefs and theological questions have been clearfied,naming it as the cow shows the esssensc.,Normally as writers when we sit to write a book we choose to name a chapter with most favoured phrase .Just like a newspaper chooses his headline with care, relevance and to attack attension.

CUSTOMS AND RITES

Many people confuse customs with religious commandments. RELIGIOUS CUSTOMS AND RITE S LIKE  clothes, eating habits,language,dress,music ,local habits cannot be equalized as a  belief or testimony, The Muslim religion fundamental principles like Aaeman.klama, Nimaz,zakat,haj are the essentials of the faith, The customs are localized and can be different in a country. Unfortunately sometimes religious good is diluted with customs or even the behaviour of a man or women calling him or her belonging to a particular religion.

A THEIF,KILLER OR A PROSTITUTE ,CORRUPT MAN ,ADULATOR,EVIL WHISPHERER,CONSPIRATOR OR A LAIR HAS NO PLACE IN ISLAM. Even if he names himself as a Muslim he cannot be regarded as a muslim.Even names were  not changed after  conversion during the days of prophet.

“We believe in Allah, and the revelation given to us, and to Abraham, Ismail, Isaac, Jacob, and the Tribes, and that given to Moses and Jesus, and that given to (all) prophets from their Lord: We make no difference between one and another of them: And we bow to Allah (in Islam).”

Universal brotherhood concept.

Thus these verses of Quran make the ISLAM as a religion broader than some of us define or malign it. It has a principle of universal brotherhood. A Muslim is permitted to marry a Jew or a Christian or anyone who believe in one God ,A Muslim is allowed to have food of Jews .Christians or any one provided it is clean and free from forbidden items like blood, swine flesh etc Even under extreme condition he is allowed to eat what is forbidden but it should be in utter need not as a luxury .Thus having a boarder approach to life than the ordinary suicidal tendency and despondency.

.There is no commandment to be non-vegetarian or vegetarian. A Muslim can be one who does not eat meat,. The man has been born and left in the jungle .He was a hunter, all hunt to eat. Thus all ancient culture was non-vegeterian.The Islam does not ask you to eat this or that, but gives us liberty even to eat the forbidden items to keep alive.

It is nothing to do with the TAQWA , ONESS OF God. The essential component of the faith, which is a commonality in all religions. The conceptual principle which determines your faith,Food is optional and allowed under duress or in dare need, but hunger strike s or death by self suicidal acts is strictly forbidden.

The cow named surah or chapter of Quran is revealed in Medina and have details of the legislature and more detailed versions than those revelled to Mohammad in Mecca.

The cow in Herbrew

In herbrew the yellow heifer defines and described as choice of God for sacrifice  to Mosses like the Issac to Ibrahim is described as HAEGGEL ,:The sin of the calf .

 THE Apis Bull of EGYPT

      In Egyypt, the Apis Bull was the  object  of worship, . Among the Egyptians’ and Hebrews’  the wild bull, was widely worshipped, often as the Lunar Bull .Thus these cultures regarded the cattle more scared than the Hinduss,The one question which come to mind is that it is a custom more than a religious myth as some of immanent scholar of Sanskrit and Vedic literature have reported, Whatever ,the cow or the ox have been important an essential part of the global culture and customs from times immoral ..

MOUNT SINSIS

When Mosses went up onto Mount Sinaia to receive the Ten Commandments (Exodus 19:20 he left the Israelites for forty days and forty nights. The Israelites feared that he would not return .They  complied and gathered golden earrings. Then  melted them and constructed the golden calf.The Israelites made offerings and celebrated. In Hebrew the incident is known as ???’ ha‘?ggel or “The Sin of the Calf”.

CRETAN BULL OF GREEKS

          It is also mentioned as  Cretan Bull of Greek myth. Thus the Indian Myth of the cattle being scared is shared by other culture too like the Herbrew,Arabs,Egyptians and Greeks.It is thus a ritual or custom than a command ment of God and thus has different versions. The concept of GOD being the only one to be worshiped and that it has no physical form has been discussed in our earliest discussion in these web pages too. The God is a tagali= light source too powerful  and illuminative this realty is accepted in all the religions  books including VEDAS

 

 

In Moses farewell blessing to the Jewish people, he describes Joseph as an “ox”: “The most eminent, his [is the power of the] ox that is given to him….”(Deut. 33:17) In Jacob’s blessing to Joseph, the same word for “ox” appears, although in a different meaning, that of “wall”: “A fruitful son is Joseph, a fruitful son above the [evil] eye; daughters tread over the wall [to gaze on him]. (Gen. 49:22) The words for “over the wall” in Hebrew are “alei shur“, which if slightly revocalized can be read: “Ascend, O ox!” (”aleh” “shor

Thus they devised to make the Golden Calf, which is also called an “ox”, with the powerful magic tools in their mouths, which upset the order of the supernal realms. All the powers we mentioned combined together – that of the evil [generated by the Jews' sin], that of the magic [powers they possessed], that of the holiness of Aaron’s, and that of the holy Name etched in the golden plate that was used to elevate Joseph from the Nile. This combination produced the Golden Calf, which was animated by the spiritual life-force of their grandfather Be’or. [Be'or] thus ascended from the vegetable to the animal kingdom, and [the Mixed Multitude] accepted him as their leader, who would inform them of the future and tell them whatever they would need to know. And all this was possible by the fact that they made the Israelites sin, as mentioned.

The soul of the wicked Be’or, which was present in this calf, was who yelled out, saying “This is your G-d, O Israel!” (Ex. 32:4) as our sages have stated. (See Pirkei d’Rabbi Eliezer 25)

DHARMA. Hindus must realize that enriching the life of bovine and other useful animals is DHARMA. Making efforts to build a healthy and large population of cattle in India is DHRAMA. On the path of DHARMA, a wise man is not perturbed by death since he knows that soul is immortal – “Weapons cannot cut it nor can fire burn it ; water cannot drench it nor can wind make it dry.ANIL CHAWLA ,1999 WROTE – Srimad Bhagavad-Gita (also called Gita) is one of the most sacred books for Hindus. During the war of MAHABHARAT, just before the beginning of the war, Arjuna who was a great warrior suddenly developed self-doubt and raised fundamental existentialist questions about the purpose of life and hence of war which would have led to the annihilation of so many who were very dear to him. Lord Krishna who was a friend of Arjuna and was also driving his chariot during the war delivered the sermon of Gita clarifying the fundamental questions raised.

SWAMI VIVEKANANDA ON BEEF

(This letter was published in Letters to Editor, Hindustan Times dated 3rd January, 2002)
(Please visit ArchivesHT  for more details)
 

Swami Vivekananda said: “You have always to remember that because a little social custom is going to be changed, you are not going to lose your religion, not at all. Remember these customs have already been changed. There was a time in this very India when, without eating beef, no Brahmin could remain a Brahmin ; you read in the Vedas how, when a sanyasin, a king, or a great man came into a house, the best bullock was killed, how in time it was found that as we were an agricultural race, killing the best bulls meant annihilation of the race. Therefore, the practice was stopped, and a voice;

Thus it is clear the respect of the cows and the cattle as a whole is shared by all religious books.Some eat it and some don not is a custom and no a religion.Howerver ,in Jammu and kahmir state of India ,a muslim majority state has the constitution which bans the cow slaughter and one finds very few muslims in Kashmir who willingly eat beef.This is not true of the other Indian or Pakistani muslims who eat beef as choice.Even the jummuiets from the borders and even those coming from tribal belt in Kashmir the Khatans etc do eat beef outside their state but not the kashmiri speaking muslims and Pandits.This too thus indicates it that is a custom of a race and not a religiom.In rest of ASIA ,MIDDLEEAST Goats are sacrificed on EID –UL-BAKAR,.The goat meat is phefered in all these places but not in Kashmir where the muslims and Hindu too like sheep meat and that too with fat and not too lean, These are habits and not religion. Thus a muslim can be  Muslim without eating beef.

This verse refers to the story of the golden calf made and worshipped by the Israelites after their exodus from Egypt. While Moses (Musa (as.)) was in communion with God on the heights of mount Sinai, while revelation was in the process of being sent down to him, while God was manifesting His presence to Moses and divulging to him the secrets of creation and of the structure of religion, some of the Israelites (under the direction and supervision of a person called Samiri) constructed and worshipped a statue of a golden calf

COWS AND ENVIRONMENT

The use of degraded agriculture wastes and deoiled cakes  by COWS and their conversion into milk. Meat and other valuable products ,saves of wastage and consuming non-edible nitrogenous matter like cellulose and deoiled cakes and in turn adding nitrogen to the soil hells us to maintain soil health and nitrogen cycle. The draught power has been detailed in our earlier articles .It helps India alone to save millions do dollars ,The fossil fuel price and carbon burn is a vital for the climatic change ,thus the role of cows in its desired ratio per hectare is helpful but not harmful,howerve the numbers are to be limited which is happenening as cross breeds give more per animal productivity than locals and cross bred ratio increasing in the Hindi northern belt speaks volumes. The problems encounter both under rained and irrigatated cropping systems is with male and unproductive animals .A survival of the fittest formula even does not apply here, thus serious thought is needed, We have proposed a unified use of these animals for research and development by all drug and medicine testing firms,organizations,vet college, medical experimental stations and the energy requiring institute and NGOs .A detailed plan to mitigate this and other customary problems have been suggested with in framework of the constitution and the populace cultural ethos.

PHILOSOPHY OF GITA by anil chawla describing the economics of the cattle.
(The following extracts are from his free web publications,and are cited here as scolarly references from him and not me)

For the death of him who is born is certain ; and the rebirth of him who is dead is inevitable. It does not, therefore, behove you to grieve over an inevitable event.” (Verse 27, Chapter 2, Srimad Bhagavad-Gita)

Lord Krishna says that it is wrong to grieve about death since death is like a change of clothes. Soul gives up its old clothes and takes on new ones. Focussing on life and accepting death as an integral part of life – is the essence of Gita which applies to every aspect of human life. It is this philosophy that enabled Krishna to be an animal-lover and yet be a good hunter. Understanding the philosophy of Gita is necessary to comprehend animal-rearing.

In the field of animal rearing Consumption and Protection are two sides of the same coin. One who consumes is the one who protects and vice-versa. Muslims in India sacrifice goats at the time of Eid-ul-zuha and consume the meat. The other facet of this is that Muslims feed and take care of a goat for a full year or alternatively pay a big sum to one who has taken care of the sacrificial goat. On the other hand there are Jains who do not eat meat and do nothing to rear or take care of goats. India is the largest consumer of goat meat in the world and India has the largest goat population in the world. Pakistan does not consume pig-meat and it has almost no pigs. During the past thirty years the consumption of eggs and chicken in India has increased almost tenfold. This has led to the poultry industry getting a big boost and there has been an unprecedented increase in the population of hens. It will not be an exaggeration to say that if mankind stopped consuming eggs and chicken completely, hen as a species may vanish from the surface of earth.

Cow is considered sacred and is worshipped in India while in adjoining Pakistan there are no such beliefs. Yet, when a cow dies in India, its average carcass weight is just about 103 Kg and in Pakistan the average carcass weight is about 185 Kg. The figure for USA and Germany is about 315 Kg. In other words, cows in India are not butchered but are tortured to a slow and painful death by hunger. A foolish interpretation of DHARMA (loosely translated as duty or religion) has led some Indians to oppose cow slaughter leading to a situation where cows are neither cared for nor protected. A refusal to accept death of cow has made life hell for cow. Moving stray on roads Indian cow is forced to eat polythene bags and die a painful death. All talks of non-violence and pity by religious leaders sound nice but cannot give the essential ingredients of life to Indian cows.

Milk Production in India has increased considerably during the past three decades after National Dairy Development Board launched Operation Flood. Yet, the per capita availability of milk in India in 1997 was just about 58.5 Kg per annum. The corresponding figure for Pakistan is 116.3 Kg, Germany – 238.8 Kg, Russia – 145.1 Kg, USA – 251.3 Kg. Some persons may be surprised that the per capita availability of milk in India is just about half of that in Pakistan though economically Pakistan is almost in the same bracket as India. The misguided orthodox zealots who oppose all mechanized slaughter houses and meat exports often argue that continuous slaughtering of progeny of cows will lead to elimination of cows and bulls from the country causing a milk famine. The fact is just opposite – the countries that consume cow-meat have substantially higher milk availability.

The economics of animal rearing is based on milk as well as meat. Whenever any cow or buffalo gives birth, there is an almost equal probability of a male or female calf. A dairy farmer rears a female calf in expectation of milk, while a male is reared for either meat or for use as a draught animal. It is the combined economics of milk, meat and harness that makes investments possible in dairy industry. If any of the three pillars is disturbed, the economics of dairy industry is badly affected. In most developed countries, there is no use of animal in harness but demand for meat helps balance the economics of dairy industry. In ancient India, extensive use of bullocks as draught animals made dairy farming viable even without the use of meat. In modern India, on one hand, subsidies on electricity for farming, tractors, diesel etc. have eliminated the need to use animals for ploughing and carriage of goods. On the other hand, a plethora of restrictions on bovine meat have effectively prevented Indian dairy farmers from getting a reasonable price for bovine meat. This has rendered male bovine animals completely useless thereby affecting the economics and growth of the Indian dairy industry.

India exports almost ten million tonnes of de-oiled cakes every year to countries like Pakistan, Iran, Thailand, Korea, Japan etc. who have a better developed dairy industry. De-oiled cakes are rich in proteins and are primarily used as ingredient for animal feed. In addition to causing protein deficiency in an impoverished country like India, export of de-oiled cakes disturbs the Nitrogen cycle of nature causing the soil to lose fertility. Animals perform a useful ecological function by consuming non-edible nitrogenous matter like cellulose and de-oiled cakes. Faecal matter of animals completes the nitrogen cycle and enriches the soil. In the absence of sufficiently large number of animals, agriculture starts losing its long term viability. Hence, it is necessary that the economics of Indian dairy farming is strengthened so that Indian de-oiled cakes can be fed to Indian animals which are essential pre-requisite for maintaining soil fertility over the long term.

Cow dung also plays a minor albeit important role in dairy economics. Heavy subsidies on chemical fertilizers have reduced the demand for cow dung. This has made it impossible for any dairy farmer to feed a non-milking cow.

Dairy industry plays a vital role in the agro-based economics of India. Strengthening dairy industry is essential for removing poverty of the large majority of Indian population which is living even today in rural areas. The three pillars of dairy farming economics – Milk, Meat and Use in Harness – need to be strengthened. Just as National Dairy Development Board has done commendable work in the field of milk, there is an urgent need for similar work in the field of meat. Government of India should set a target to eliminate exports of de-oiled cakes in the next five to ten years. Subsidies on tractors, diesel, farm-use-electricity, chemical fertilizers should be gradually eliminated. Use of mineral fuel based vehicles should be banned in certain dense areas of cities and in such areas only human and animal powered vehicles should be permitted. This will not only increase utility of animals in harness but will also help reduce pollution in Indian city centres that have become almost inhabitable. Use of modern technology should be promoted in animal powered vehicles.

Hindu religion is based on “SANATAN” truths – facts and principles that have always been true and shall always are. It was this understanding of SANATAN truth that led the Lord Shiva who is known as a God of destruction being also called Lord PASHUPATINATH, the deity that is the owner and protector of all animals. Shiva family carries with it a symbolism that illustrates the concept of mutual dependence of beings for food and other needs. The vehicle of Shiva is a bullock while his wife Parvati’s vehicle is a lion that preys on bullock. Shiva’s son Ganesha moves around on a rat while snakes (who eat rats) hang around the neck of Lord Shiva. On the other hand snakes are devoured by peacock which is the vehicle of Shiva’s other son Kartik. Cycle of nature is based on such mutual dependence and mutual checks & balances. One who understands this cycle and does not get disturbed by death is a wise man. He accepts death as a necessary routine. Commitments towards life rather than concerns about death are the guiding principles for all his actions. DHARMA (loosely translated as duty or religion) is not in avoiding death nor is it in fearing death nor is it in worrying about or grieving over death. Life and living life is DHARMA. If moved by the fears of death non-violence weakens life and if violence accepts death to eventually strengthen life, then violence is DHARMA and non-violence is ADHARMA (antonym or antitheses of DHARMA). This is the philosophy of Gita and this is the way of upliftment of any society.

 

 

to be continued

About the Author

Dedicated to my teachers in school like AB AHAD AKOON,MOHD SADULLAH SOFI.SARWAR NAND,NARINGEN NATH AND Gope krishan moza

I have apleasure to refer many views and comments from the Dr Anil Chawlas web paper who access is free for like as of mine,nevertheless I acknowkedge and thank him for its use

Thai Cooking


Development and transfer of food processing technology for hilltribe agricultural produce to upgrade hilltribe diets and provide saleable products: Final report


Development and transfer of food processing technology for hilltribe agricultural produce to upgrade hilltribe diets and provide saleable products: Final report




Food and Population in a Northeast Thai Village (Monographs of the Center for Southeast Asian Studies, Kyoto University)


Food and Population in a Northeast Thai Village (Monographs of the Center for Southeast Asian Studies, Kyoto University)


$10.95


 

Thailand Food Service Report

Influenza A Virus

Variants and subtypes

Variants are identified and named according to the isolate that they are like and thus are presumed to share lineage (example Fujian flu virus like); according to their typical host (example Human flu virus); according to their subtype (example H3N2); and according to their deadliness (example LP, Low Pathogenic). So a flu from a virus similar to the isolate A/Fujian/411/2002(H3N2) is called Fujian flu, human flu, and H3N2 flu.

Variants are sometimes named according to the species (host) the strain is endemic in or adapted to. The main variants named using this convention are:

Bird flu

Human flu

Swine flu

Horse flu

Dog flu

Cat flu

Variants have also sometimes been named according to their deadliness in poultry, especially chickens:

Low Pathogenic Avian Influenza (LPAI)

Highly Pathogenic Avian Influenza (HPAI), also called: deadly flu or death flu

Most known strains are extinct strains. For example, the annual flu subtype H3N2 no longer contains the strain that caused the Hong Kong Flu.

Annual flu

Main article: Flu season

The annual flu (also called “seasonal flu” or “human flu”) in the U.S. “results in approximately 36,000 deaths and more than 200,000 hospitalizations each year. In addition to this human toll, influenza is annually responsible for a total cost of over $10 billion in the U.S.” .

The annually updated trivalent influenza vaccine consists of hemagglutinin (HA) surface glycoprotein components from influenza H3N2, H1N1, and B influenza viruses.

The dominant strain in January 2006 was H3N2. Measured resistance to the standard antiviral drugs amantadine and rimantadine in H3N2 has increased from 1% in 1994 to 12% in 2003 to 91% in 2005.

“[C]ontemporary human H3N2 influenza viruses are now endemic in pigs in southern China and can reassort with avian H5N1 viruses in this intermediate host.”

Structure and genetics

See also: H5N1 genetic structure

“The physical structure of all influenza A viruses is similar. The virions or virus particles are enveloped and can be either spherical or filamentous in form. In clinical isolates that have undergone limited passages in eggs or tissue culture, there are more filamentous than spherical particles, whereas passaged laboratory strains consist mainly of spherical virions.”

The Influenza A virus genome is contained on eight single (non-paired) RNA strands that code for eleven proteins (HA, NA, NP, M1, M2, NS1, NEP, PA, PB1, PB1-F2, PB2). The total genome size is 13,588 bases. The segmented nature of the genome allows for the exchange of entire genes between different viral strains during cellular cohabitation. The eight RNA segments are:

HA encodes hemagglutinin (about 500 molecules of hemagglutinin are needed to make one virion) “The extent of infection into host organism is determined by HA. Influenza viruses bud from the apical surface of polarized epithelial cells (e.g. bronchial epithelial cells) into lumen of lungs and are therefore usually pneumotropic. The reason is that HA is cleaved by tryptase clara which is restricted to lungs. However HAs of H5 and H7 pantropic avian viruses subtypes can be cleaved by furin and subtilisin-type enzymes, allowing the virus to grow in other organs than lungs.”

NA encodes neuraminidase (about 100 molecules of neuraminidase are needed to make one virion).

NP encodes nucleoprotein.

M encodes two matrix proteins (the M1 and the M2) by using different reading frames from the same RNA segment (about 3000 matrix protein molecules are needed to make one virion).

NS encodes two distinct non-structural proteins (NS1 and NEP) by using different reading frames from the same RNA segment.

PA encodes an RNA polymerase.

PB1 encodes an RNA polymerase and PB1-F2 protein (induces apoptosis) by using different reading frames from the same RNA segment.

PB2 encodes an RNA polymerase.

The genome segments have common terminal sequences, and the ends of the RNA strands are partially complementary, allowing them to bond to each other by hydrogen bonds. After transcription from negative-sense to positive-sense RNA the +RNA strands get the cellular 5′ cap added by cap snatching, which involves the viral protein NS1 binding to the cellular pre-mRNAs. The cap is then cleaved from the cellular pre-mRNA using a second viral protein, PB2. The short oligo cap is then added to the influenza +RNA strands, allowing its processing as messenger RNA by ribosomes. The +RNA strands also serve for synthesis of -RNA strands for new virions.

The RNA synthesis and its assembly with the nucleoprotein takes place in the cell nucleus, the synthesis of proteins takes place in the cytoplasm. The assembled virion cores leave the nucleus and migrate towards the cell membrane, with patches of viral transmembrane proteins (hemagglutinin, neuraminidase and M2 proteins) and an underlying layer of the M1 protein, and bud through these patches, releasing finished enveloped viruses into the extracellular fluid.

In nonhumans

See H5N1 for the current epizootic (an epidemic in nonhumans) and panzootic (a disease affecting animals of many species especially over a wide area) of H5N1 influenza

Avian influenza

Main article: Avian influenza

Wild fowl act as natural asymptomatic carriers of Influenza A viruses. Prior to the current H5N1 epizootic, strains of Influenza A virus had been demonstrated to be transmitted from wild fowl to only birds, pigs, horses, seals, whales and humans; and only between humans and pigs and between humans and domestic fowl; and not other pathways such as domestic fowl to horse.

Wild aquatic birds are the natural hosts for a large variety of influenza A viruses. Occasionally viruses are transmitted from these birds to other species and may then cause devastating outbreaks in domestic poultry or give rise to human influenza pandemics.

H5N1 has been shown to be transmitted to tigers, leopards, and domestic cats that were fed uncooked domestic fowl (chickens) with the virus. H3N8 viruses from horses have crossed over and caused outbreaks in dogs. Laboratory mice have been infected successfully with a variety of avian flu genotypes.

Influenza A viruses spread in the air and in manure and survives longer in cold weather. It can also be transmitted by contaminated feed, water, equipment and clothing; however, there is no evidence that the virus can survive in well-cooked meat. Symptoms in animals vary, but virulent strains can cause death within a few days.

“Highly pathogenic avian influenza virus is on every top ten list available for potential agricultural bioweapon agents”.

Avian influenza viruses that the OIE and others test for in order to control poultry disease include: H5N1, H7N2, H1N7, H7N3, H13N6, H5N9, H11N6, H3N8, H9N2, H5N2, H4N8, H10N7, H2N2, H8N4, H14N5, H6N5, H12N5 and others.

Known outbreaks of highly pathogenic flu in poultry 1959-2003

Year

Area

Affected

Subtype

1959

Scotland

chicken

H5N1

1963

England

turkey

H7N3

1966

Ontario (Canada)

turkey

H5N9

1976

Victoria (Australia)

chicken

H7N7

1979

Germany

chicken

H7N7

1979

England

turkey

H7N7

1983

Pennsylvania (USA)*

chicken, turkey

H5N2

1983

Ireland

turkey

H5N8

1985

Victoria (Australia)

chicken

H7N7

1991

England

turkey

H5N1

1992

Victoria (Australia)

chicken

H7N3

1994

Queensland (Australia)

chicken

H7N3

1994

Mexico*

chicken

H5N2

1994

Pakistan*

chicken

H7N3

1997

New South Wales (Australia)

chicken

H7N4

1997

Hong Kong (China)*

chicken

H5N1

1997

Italy

chicken

H5N2

1999

Italy*

turkey

H7N1

2002

Hong Kong (China)

chicken

H5N1

2002

Chile

chicken

H7N3

2003

Netherlands*

chicken

H7N7

*Outbreaks with significant spread to numerous farms, resulting in great economic losses. Most other outbreaks involved little or no spread from the initially infected farms.

1979: “More than 400 harbor seals, most of them immature, died along the New England coast between December 1979 and October 1980 of acute pneumonia associated with influenza virus, A/Seal/Mass/1/180 (H7N7).”

1995: “[V]accinated birds can develop asymptomatic infections that allow virus to spread, mutate, and recombine (ProMED-mail, 2004j). Intensive surveillance is required to detect these ilent epidemics in time to curtail them. In Mexico, for example, mass vaccination of chickens against epidemic H5N2 influenza in 1995 has had to continue in order to control a persistent and evolving virus (Lee et al., 2004).”

1997: “Influenza A viruses normally seen in one species sometimes can cross over and cause illness in another species. For example, until 1997, only H1N1 viruses circulated widely in the U.S. pig population. However, in 1997, H3N2 viruses from humans were introduced into the pig population and caused widespread disease among pigs. Most recently, H3N8 viruses from horses have crossed over and caused outbreaks in dogs.”

2000: “In California, poultry producers kept their knowledge of a recent H6N2 avian influenza outbreak to themselves due to their fear of public rejection of poultry products; meanwhile, the disease spread across the western United States and has since become endemic.”

2003: In Netherlands H7N7 influenza virus infection broke out in poultry on several farms.

2004: In North America, the presence of avian influenza strain H7N3 was confirmed at several poultry farms in British Columbia in February 2004. As of April 2004, 18 farms had been quarantined to halt the spread of the virus.

2005: Tens of millions of birds died of H5N1 influenza and hundreds of millions of birds were culled to protect humans from H5N1. H5N1 is endemic in birds in southeast Asia and represents a long term pandemic threat.

2006: H5N1 spreads across the globe killing hundreds of millions of birds and over 100 people causing a significant H5N1 impact from both actual deaths and predicted possible deaths.

Swine flu

Main article: Swine Flu

Swine flu (or “pig influenza”) refers to a subset of Orthomyxoviridae that create influenza in pigs and are endemic in pigs. The species of Orthomyxoviridae that can cause flu in pigs are Influenza A virus and Influenza C virus but not all genotypes of these two species infect pigs. The known subtypes of Influenza A virus that create influenza in pigs and are endemic in pigs are H1N1, H1N2, H3N1 and H3N2.

Horse flu

Main article: Horse flu

Horse flu (or “Equine influenza”) refers to varieties of Influenza A virus that affect horses. Horse ‘flu viruses were only isolated in 1956. There are two main types of virus called equine-1 (H7N7) which commonly affects horse heart muscle and equine-2 (H3N8) which is usually more severe.

Dog flu

Main article: Dog flu

Dog flu (or “canine influenza”) refers to varieties of Influenza A virus that affect dogs. The equine influenza virus H3N8 was found to infect and kill greyhound race dogs that had died from a respiratory illness at a Florida racetrack in January 2004.

H3N8

Main article: H3N8

H3N8 is now endemic in birds, horses and dogs.

Human influenza virus

Japanese commuter wearing a face mask.

“Human influenza virus” usually refers to those subtypes that spread widely among humans. H1N1, H1N2, and H3N2 are the only known Influenza A virus subtypes currently circulating among humans.

Genetic factors in distinguishing between “human flu viruses” and “avian influenza viruses” include:

PB2: (RNA polymerase): Amino acid (or residue) position 627 in the PB2 protein encoded by the PB2 RNA gene. Until H5N1, all known avian influenza viruses had a Glu at position 627, while all human influenza viruses had a lysine.

HA: (hemagglutinin): Avian influenza HA bind alpha 2-3 sialic acid receptors while human influenza HA bind alpha 2-6 sialic acid receptors. Swine influenza viruses have the ability to bind both types of sialic acid receptors.

“About 52 key genetic changes distinguish avian influenza strains from those that spread easily among people, according to researchers in Taiwan, who analyzed the genes of more than 400 A type flu viruses.” “How many mutations would make an avian virus capable of infecting humans efficiently, or how many mutations would render an influenza virus a pandemic strain, is difficult to predict. We have examined sequences from the 1918 strain, which is the only pandemic influenza virus that could be entirely derived from avian strains. Of the 52 species-associated positions, 16 have residues typical for human strains; the others remained as avian signatures. The result supports the hypothesis that the 1918 pandemic virus is more closely related to the avian influenza A virus than are other human influenza viruses.”

Human flu symptoms usually include fever, cough, sore throat, muscle aches, conjunctivitis and, in severe cases, severe breathing problems and pneumonia that may be fatal. The severity of the infection will depend to a large part on the state of the infected person’s immune system and if the victim has been exposed to the strain before, and is therefore partially immune.

Highly pathogenic H5N1 avian influenza in a human is far worse, killing 50% of humans that catch it. In one case, a boy with H5N1 experienced diarrhea followed rapidly by a coma without developing respiratory or flu-like symptoms.

The Influenza A virus subtypes that have been confirmed in humans, ordered by the number of known human pandemic deaths, are:

H1N1 caused “Spanish Flu” and the 2009 swine flu outbreak

H2N2 caused “Asian Flu” in the late 1950s

H3N2 caused “Hong Kong Flu” in the late 1960s

H5N1 considered a global influenza pandemic threat through its spread in the mid-2000s

H7N7 has unusual zoonotic potential

H1N2 is currently endemic in humans and pigs

H9N2, H7N2, H7N3, H5N2, H10N7.

H1N1

Main article: H1N1

H1N1 is currently pandemic in both human and pig populations. A variant of H1N1 was responsible for the Spanish flu pandemic that killed some 50 million to 100 million people worldwide over about a year in 1918 and 1919. Another variant was named a pandemic threat in the 2009 swine flu outbreak. Controversy arose in October, 2005, after the H1N1 genome was published in the journal, Science, because of fears that this information could be used for bioterrorism.

H2N2

Main article: H2N2

The Asian Flu was a pandemic outbreak of H2N2 avian influenza that originated in China in 1957, spread worldwide that same year during which a influenza vaccine was developed, lasted until 1958 and caused between one and four million deaths.

H3N2

Main article: H3N2

H3N2 is currently endemic in both human and pig populations. It evolved from H2N2 by antigenic shift and caused the Hong Kong Flu pandemic of 1968 and 1969 that killed up to 750,000. “An early-onset, severe form of influenza A H3N2 made headlines when it claimed the lives of several children in the United States in late 2003.”

The dominant strain of annual flu in January 2006 is H3N2. Measured resistance to the standard antiviral drugs amantadine and rimantadine in H3N2 has increased from 1% in 1994 to 12% in 2003 to 91% in 2005.

“[C]ontemporary human H3N2 influenza viruses are now endemic in pigs in southern China and can reassort with avian H5N1 viruses in this intermediate host.”

H5N1

Main article: H5N1

H5N1 is the world’s major influenza pandemic threat.

“When he compared the 1918 virus with today’s human flu viruses, Dr. Taubenberger noticed that it had alterations in just 25 to 30 of the virus’s 4,400 amino acids. Those few changes turned a bird virus into a killer that could spread from person to person.”

H7N7

Main article: H7N7

H7N7 has unusual zoonotic potential. In 2003 in Netherlands 89 people were confirmed to have H7N7 influenza virus infection following an outbreak in poultry on several farms. One death was recorded.

H1N2

Main article: H1N2

H1N2 is currently endemic in both human and pig populations. The new H1N2 strain appears to have resulted from the reassortment of the genes of the currently circulating influenza H1N1 and H3N2 subtypes. The hemagglutinin protein of the H1N2 virus is similar to that of the currently circulating H1N1 viruses and the neuraminidase protein is similar to that of the current H3N2 viruses.

H9N2

Main article: H9N2

Low pathogenic avian influenza A (H9N2) infection was confirmed in 1999, in China and Hong Kong in two children, and in 2003 in Hong Kong in one child. All three fully recovered.

H7N2

Main article: H7N2

One person in New York in 2003 and one person in Virginia in 2002 were found to have serologic evidence of infection with H7N2. Both fully recovered.

H7N3

Main article: H7N3

In North America, the presence of avian influenza strain H7N3 was confirmed at several poultry farms in British Columbia in February 2004. As of April 2004, 18 farms had been quarantined to halt the spread of the virus. Two cases of humans with avian influenza have been confirmed in that region. “Symptoms included conjunctivitis and mild influenza-like illness.” Both fully recovered.

H5N2

Main article: H5N2

Japan’s Health Ministry said Jan, 2006 that poultry farm workers in Ibaraki prefecture may have been exposed to H5N2 in 2005. The H5N2 antibody titers of paired sera of 13 subjects increased fourfold or more.

H10N7

Main article: H10N7

In 2004 in Egypt H10N7 was reported for the first time in humans. It caused illness in two infants in Egypt. One child father is a poultry merchant.

Evolution

See also: Punctuated equilibrium

Taubenberger says:

“All influenza A pandemics since [the Spanish flu pandemic], and indeed almost all cases of influenza A worldwide (excepting human infections from avian viruses such as H5N1 and H7N7), have been caused by descendants of the 1918 virus, including “drifted” H1N1 viruses and reassorted H2N2 and H3N2 viruses. The latter are composed of key genes from the 1918 virus, updated by subsequently incorporated avian influenza genes that code for novel surface proteins, making the 1918 virus indeed the “mother” of all pandemics.

Researchers from the National Institutes of Health used data from the Influenza Genome Sequencing Project and concluded that during the ten-year period examined most of the time the hemagglutinin gene in H3N2 showed no significant excess of mutations in the antigenic regions while an increasing variety of strains accumulated. This resulted in one of the variants eventually achieving higher fitness, becoming dominant, and in a brief interval of rapid evolution rapidly sweeping through the population and eliminating most other variants.

See also

Animal virology

ACAM-FLU-A

Notes

^ “Avian influenza (” bird flu”) – Fact sheet”. WHO. http://www.who.int/mediacentre/factsheets/avian_influenza/en/. 

^ a b Klenk et al. (2008). “Avian Influenza: Molecular Mechanisms of Pathogenesis and Host Range”. Animal Viruses: Molecular Biology. Caister Academic Press. ISBN 978-1-904455-22-6. http://www.horizonpress.com/avir. 

^ a b Kawaoka Y (editor). (2006). Influenza Virology: Current Topics. Caister Academic Press. ISBN 978-1-904455-06-6 . http://www.horizonpress.com/flu. 

^ CIDRAP – Center for Infectious Disease Research And Policy Pandemic Influenza Overview

^ whitehouse.gov National Strategy for Pandemic Influenza – Introduction – “Although remarkable advances have been made in science and medicine during the past century, we are constantly reminded that we live in a universe of microbes – viruses, bacteria, protozoa and fungi that are forever changing and adapting themselves to the human host and the defenses that humans create. Influenza viruses are notable for their resilience and adaptability. While science has been able to develop highly effective vaccines and treatments for many infectious diseases that threaten public health, acquiring these tools is an ongoing challenge with the influenza virus. Changes in the genetic makeup of the virus require us to develop new vaccines on an annual basis and forecast which strains are likely to predominate. As a result, and despite annual vaccinations, the U.S. faces a burden of influenza that results in approximately 36,000 deaths and more than 200,000 hospitalizations each year. In addition to this human toll, influenza is annually responsible for a total cost of over $10 billion in the U.S. A pandemic, or worldwide outbreak of a new influenza virus, could dwarf this impact by overwhelming our health and medical capabilities, potentially resulting in hundreds of thousands of deaths, millions of hospitalizations, and hundreds of billions of dollars in direct and indirect costs. This Strategy will guide our preparedness and response activities to mitigate that impact.”

^ Daum LT, Shaw MW, Klimov AI, et al. (August 2005). “Influenza A (H3N2) outbreak, Nepal”. Emerging Infect. Dis. 11 (8): 118691. PMID 16102305. http://www.cdc.gov/ncidod/EID/vol11no08/05-0302.htm. 

“The 20032004 influenza season was severe in terms of its impact on illness because of widespread circulation of antigenically distinct influenza A (H3N2) Fujian-like viruses. These viruses first appeared late during the 20022003 influenza season and continued to persist as the dominant circulating strain throughout the subsequent 20032004 influenza season, replacing the A/Panama/2007/99-like H3N2 viruses (1). Of the 172 H3N2 viruses genetically characterized by the Department of Defense in 20032004, only 1 isolate (from Thailand) belonged to the A/Panama-like lineage. In February 2003, the World Health Organization (WHO) changed the H3N2 component for the 20042005 influenza vaccine to afford protection against the widespread emergence of Fujian-like viruses (2). The annually updated trivalent vaccine consists of hemagglutinin (HA) surface glycoprotein components from influenza H3N2, H1N1, and B viruses.”

^ a b Mahmoud, Adel A. F; Institute of Medicine; Knobler, Stacey; Mack, Alison (2005). The threat of pandemic influenza: are we ready?: workshop summary. Washington, D.C: National Academies Press. pp. 126. ISBN 0-309-09504-2. http://www.nap.edu/books/0309095042/html/126.html. “H5N1 virus is now endemic in poultry in Asia (Table 2-1) and has gained an entrenched ecological niche from which to present a long-term pandemic threat to humans. At present, these viruses are poorly transmitted from poultry to humans, and there is no conclusive evidence of human-to-human transmission. However, continued, extensive exposure of the human population to H5N1 viruses increases the likelihood that the viruses will acquire the necessary characteristics for efficient human-to-human transmission through genetic mutation or reassortment with a prevailing human influenza A virus. Furthermore, contemporary human H3N2 influenza viruses are now endemic in pigs in southern China (Peiris et al., 2001) and can reassort with avian H5N1 viruses in this ‘intermediate host.’ Therefore, it is imperative that outbreaks of H5N1 disease in poultry in Asia are rapidly and sustainably controlled. The seasonality of the disease in poultry, together with the control measures already implemented, are likely to reduce temporarily the frequency of H5N1 influenza outbreaks and the probability of human infection.” 

^ Clinical Services Journal article Avian influenza issues analysed published March 2006

^ MicrobiologyBytes: Virology: Orthomyxoviruses

^ UniProtKB/Swiss-Prot entry P09345 Complete sequence of a cDNA clone of the hemagglutinin gene of influenza A/Chicken/Scotland/59 (H5N1) virus: comparison with contemporary North American and European strains.

^ Mahmoud, Adel A. F (2005) p 30

^ Mahmoud, Adel A. F (2005) p 82

“Interestingly, recombinant influenza viruses containing the 1918 HA and NA and up to three additional genes derived from the 1918 virus (the other genes being derived from the A/WSN/33 virus) were all highly virulent in mice (Tumpey et al., 2004). Furthermore, expression microarray analysis performed on whole lung tissue of mice infected with the 1918 HA/ NA recombinant showed increased upregulation of genes involved in apoptosis, tissue injury, and oxidative damage (Kash et al., 2004). These findings were unusual because the viruses with the 1918 genes had not been adapted to mice. The completion of the sequence of the entire genome of the 1918 virus and the reconstruction and characterization of viruses with 1918 genes under appropriate biosafety conditions will shed more light on these findings and should allow a definitive examination of this explanation. Antigenic analysis of recombinant viruses possessing the 1918 HA and NA by hemagglutination inhibition tests using ferret and chicken antisera suggested a close relationship with the A/swine/Iowa/30 virus and H1N1 viruses isolated in the 1930s (Tumpey et al., 2004), further supporting data of Shope from the 1930s (Shope, 1936). Interestingly, when mice were immunized with different H1N1 virus strains, challenge studies using the 1918-like viruses revealed partial protection by this treatment, suggesting that current vaccination strategies are adequate against a 1918-like virus (Tumpey et al., 2004).”

^ Mahmoud, Adel A. F (2005) p 285

“As of October 2001, the potential for use of infectious agents, such as anthrax, as weapons has been firmly established. It has been suggested that attacks on a nation agriculture might be a preferred form of terrorism or economic disruption that would not have the attendant stigma of infecting and causing disease in humans. Highly pathogenic avian influenza virus is on every top ten list available for potential agricultural bioweapon agents, generally following foot and mouth disease virus and Newcastle disease virus at or near the top of the list. Rapid detection techniques for bioweapon agents are a critical need for the first-responder community, on a par with vaccine and antiviral development in preventing spread of disease.”

^ “Avian influenza A(H5N1)- update 31: Situation (poultry) in Asia: need for a long-term response, comparison with previous outbreaks”. Epidemic and Pandemic Alert and Response (EPR). WHO. 2004. http://www.who.int/csr/don/2004_03_02/en/. 

Known outbreaks of highly pathogenic flu in poultry 1959-2003.

^ NCBI – NLM – NIH National Center for Biotechnology Information (part of) U.S. National Library of Medicine (part of) National Institutes of Health (part of) US Government – Science. 1982 Feb 26;215(4536):1129-31. – Mass mortality of harbor seals: pneumonia associated with influenza A virus. – “More than 400 harbor seals, most of them immature, died along the New England coast between December 1979 and October 1980 of acute pneumonia associated with influenza virus, A/Seal/Mass/1/180 (H7N7). The virus has avian characteristics, replicates principally in mammals, and causes mild respiratory disease in experimentally infected seals. Concurrent infection with a previously undescribed mycoplasma or adverse environmental conditions may have triggered the epizootic. The similarities between this epizootic and other seal mortalities in the past suggest that these events may be linked by common biological and environmental factors.”

^ Mahmoud, Adel A. F (2005) p 15

“Unlike most other affected countries, Indonesia also instituted mass vaccination of healthy domestic birds against H5N1, followed by routine vaccination (China has a similar policy; other Asian countries are considering it [ProMED-mail, 2004j]) (Soebandrio, 2004). This is a risky strategy, because vaccinated birds can develop asymptomatic infections that allow virus to spread, mutate, and recombine (ProMED-mail, 2004j). Intensive surveillance is required to detect these ilent epidemics in time to curtail them. In Mexico, for example, mass vaccination of chickens against epidemic H5N2 influenza in 1995 has had to continue in order to control a persistent and evolving virus (Lee et al., 2004).”

^ CDC Centers for Disease Control and Prevention – Transmission of Influenza A Viruses Between Animals and People

^ Mahmoud, Adel A. F (2005) p 27

^ BBC News Early bird flu warning for Dutch – 6 November 2005

^ a b Tweed SA, Skowronski DM, David ST, et al. (December 2004). “Human illness from avian influenza H7N3, British Columbia”. Emerging Infect. Dis. 10 (12): 21969. PMID 15663860. http://www.cdc.gov/ncidod/EID/vol10no12/04-0961.htm. 

^ CDC Key Facts About Avian Influenza (Bird Flu) and Avian Influenza A (H5N1) Virus

^ Bloomberg News article Scientists Move Closer to Understanding Flu Virus Evolution published August 28, 2006

^ Chen GW, Chang SC, Mok CK, et al. (September 2006). “Genomic signatures of human versus avian influenza A viruses”. Emerging Infect. Dis. 12 (9): 135360. PMID 17073083. http://www.cdc.gov/ncidod/EID/vol12no09/06-0276.htm. 

^ de Jong MD, Bach VC, Phan TQ, et al. (February 2005). “Fatal avian influenza A (H5N1) in a child presenting with diarrhea followed by coma”. N. Engl. J. Med. 352 (7): 68691. doi:10.1056/NEJMoa044307. PMID 15716562. http://content.nejm.org/cgi/content/short/352/7/686. 

^ Mahmoud, Adel A. F (2005) p 7

^ Detailed chart of its evolution here at PDF called Ecology and Evolution of the Flu

^ Mahmoud, Adel A. F (2005) p 115

“There is particular pressure to recognize and heed the lessons of past influenza pandemics in the shadow of the worrisome 20032004 flu season. An early-onset, severe form of influenza A H3N2 made headlines when it claimed the lives of several children in the United States in late 2003. As a result, stronger than usual demand for annual flu inactivated vaccine outstripped the vaccine supply, of which 10 to 20 percent typically goes unused. Because statistics on pediatric flu deaths had not been collected previously, it is unknown if the 20032004 season witnessed a significant change in mortality patterns.”

^ Reason New York Times This Season’s Flu Virus Is Resistant to 2 Standard Drugs By Altman Published: January 15, 2006

^ New York Times Published: November 8, 2005 – Hazard in Hunt for New Flu: Looking for Bugs in All the Wrong Places

^ a b CDC Avian Influenza Infection in Humans

^ CBS News article Dozens In Japan May Have Mild Bird Flu January 2006.

^ Ogata T, Yamazaki Y, Okabe N, Nakamura Y, Tashiro M, et al. (July 2008). Human H5N2 Avian Influenza Infection in Japan and the Factors Associated with High H5N2-Neutralizing Antibody TiterJ Epidemiol 18: 160-6.

^ niaid.nih.gov Timeline of Human Flu Pandemics

^ CDC Article 1918 Influenza: the Mother of All Pandemics by Jeffery K. Taubenberger published January 2006

^ Science Daily article New Study Has Important Implications For Flu Surveillance published October 27, 2006

Further reading

Official sources

Further information: H5N1

Avian influenza and Influenza Pandemics from the Centers for Disease Control and Prevention

Avian influenza FAQ from the World Health Organization

Avian influenza information from the Food and Agriculture Organization

U.S. Government’s avian influenza information website

European Centre for Disease Prevention and Control (ECDC) Stockholm, Sweden

General information

Further information: Flu

“The Bird Flu and You” Full-color poster provided by the Center for Technology and National Security Policy at the National Defense University, in collaboration with the National Security Health Policy Center

Influenza Report 2006 Online book. Research level quality information. Highly recommended.

Special issue on avian flu from Nature

Nature Reports: Homepage: Avian Flu

Beigel JH, Farrar J, Han AM, et al. (September 2005). “Avian influenza A (H5N1) infection in humans”. N. Engl. J. Med. 353 (13): 137485. doi:10.1056/NEJMra052211. PMID 16192482. http://content.nejm.org/cgi/content/full/353/13/1374. 

Pandemic Influenza: Domestic Preparedness Efforts Congressional Research Service Report on Pandemic Preparedness.

A guide to bird flu and its symptoms from BBC Health

A Variety of Avian Flu Images and Pictures

Avian flu, bioterror, animals (page in an online book) “Highly pathogenic avian influenza virus is on every top ten list available for potential agricultural bioweapon agents”

‘The Threat of Bird Flu’: HealthPolitics.com

Is a Global Flu Pandemic Imminent? from Infection Control Today.

Bird Flu is a Real Pandemic Threat to Humans by Leonard Crane, author of Ninth Day of Creation.

Links to Bird Flu pictures (Hardin MD/Univ of Iowa)

Flu Wiki

Yoshihiro Kawaoka (2006). Influenza Virology: Current Topics. Caister Academic Pr. ISBN 1-904455-06-9. 

Francisco Sobrino; Thomas Mettenleiter (2008). Animal Viruses: Molecular Biology. Caister Academic Pr. ISBN 1-904455-22-0. 

News

Current status (Google news of avian OR bird flu OR influenza)

Flu Breaking News Avian flu, common symptom, influenza vaccine and flu shot and latest news

Global Pandemic News : 247 online news feeds on the threat of Bird Flu and a Global Pandemic

External links

Influenza Research Database Database of influenza genomic sequences and related information.

Viralzone: Influenzavirus A

Health-EU portal EU response to influenza

European Commission – Public Health EU coordination on Pandemic (H1N1) 2009

v  d  e

Influenza

General topics

Research – Vaccine – Treatment – Genome sequencing – Reassortment – Superinfection – Season

Influenza viruses

Orthomyxoviridae – Influenza A – Influenza B – Influenza C

Influenza A virus

Subtypes

H1N1 – H1N2 – H2N2 – H2N3 – H3N1 – H3N2 – H3N8 – H5N1 – H5N2 – H5N3 – H5N8 – H5N9 – H7N1 – H7N2 – H7N3 – H7N4 – H7N7 – H9N2 – H10N7

H1N1

       Pandemics

1918 flu pandemic (Spanish flu) – 2009 flu pandemic (Swine flu)

Science

2009 A/H1N1

H5N1

Science

Genetic structure – Transmission and infection – Global spread – Clinical Trials – Human mortality – Social impact – Pandemic preparation

        Outbreaks

Croatia (2005) – India (2006) – UK (2007) – West Bengal (2008)

Treatments

Antiviral drug

Arbidol – adamantane derivatives (Amantadine, Rimantadine) – neuraminidase inhibitors (Oseltamivir, Laninamivir, Peramivir, Zanamivir)

Experimental (Peramivir)

Flu vaccines

FluMist – Fluzone

Influenza epidemics & pandemics

       Pandemics

Russian flu (18891890) – Spanish flu – Asian flu – Hong Kong flu – 2009 flu pandemic

Epidemics

Russian flu (19771978) – Fujian flu (H3N2)

Non-human

Mammals

Canine influenza – Cat influenza – Equine influenza (2007 Australian outbreak) – Swine influenza

Non-mammals

Avian influenza – Fujian flu (H5N1)

Related

Influenza-like illness

v  d  e

Infectious diseases  Viral diseases (A8034, 042079)

Oncovirus

DNA virus: HBV (Hepatocellular carcinoma)  HPV (Cervical cancer)  Kaposi’s sarcoma-associated herpesvirus (Kaposi’s sarcoma)  Epstein-Barr virus (Nasopharyngeal carcinoma, Burkitt’s lymphoma, Primary central nervous system lymphoma)  MCPyV (Merkel cell cancer)  SV40

RNA virus: HCV (Hepatocellular carcinoma)  HTLV-I (Adult T-cell leukemia/lymphoma)

Immune disorders

HIV (AIDS)

Central

nervous system

Encephalitis/

meningitis

DNA virus: JCV (Progressive multifocal leukoencephalopathy)

RNA virus: MeV (Subacute sclerosing panencephalitis)  LCV (Lymphocytic choriomeningitis)  Arbovirus encephalitis  Orthomyxoviridae (probable) (Encephalitis lethargica)  RV (Rabies)

Myelitis

Poliovirus (Poliomyelitis, Post-polio syndrome)  HTLV-I (Tropical spastic paraparesis)

Eye

Cytomegalovirus (Cytomegalovirus retinitis)  HSV (Herpetic keratitis)

Cardiovascular

CBV (Pericarditis, Myocarditis)

Respiratory

system/

acute viral

nasopharyngitis/

viral pneumonia

DNA virus

Epstein-Barr virus (EBV infection/Infectious mononucleosis)  Cytomegalovirus

RNA virus

IV: SARS coronavirus (Severe acute respiratory syndrome)

V, Orthomyxoviridae: Influenzavirus A/B/C (Influenza/Avian influenza)

V, Paramyxovirus: Human parainfluenza viruses (Parainfluenza)  RSV  hMPV

Digestive system

Oropharynx/Esophagus

MuV (Mumps)  Cytomegalovirus (Cytomegalovirus esophagitis)

Gastroenteritis/

diarrhea

DNA virus: Adenovirus (Adenovirus infection)

RNA virus: Rotavirus  Norovirus  Astrovirus  Coronavirus

Hepatitis

DNA virus: HBV (B)

RNA virus: CBV  HAV (A)  HCV (C)  HDV (D)  HEV (E)  HGV (G)

Pancreatitis

CBV

Skin and

mucous membrane

lesions,

including exanthem

DNA virus

Herpesviridae

HSV (Herpes simplex, Herpetic whitlow)  VZV (Chickenpox, Herpes zoster)  Human herpesvirus 6/Roseolovirus (Exanthema subitum)  KSHV (Kaposi’s sarcoma)  Herpes B Virus

Poxviridae

Variola (Smallpox)  MoxV (Monkeypox)  CV (Cowpox)  VV (Vaccinia)  MCV (Molluscum contagiosum)

Other

HPV (Wart/Plantar wart)  Parvovirus B19 (Erythema infectiosum, Reticulocytopenia)

RNA virus

MeV (Measles)  Rubella virus (Rubella, Congenital rubella syndrome)

picornavirus: CAV (Hand, foot and mouth disease, Herpangina)  FMDV (Foot-and-mouth disease)

Urogenital

BK virus  MuV (Mumps)

see also DNA antivirals, RNA antivirals, Antiretroviral drug

Categories: Animal virology | Influenza A virus subtype H5N1 | Microbiology | Orthomyxoviridae | Zoonoses
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